跳到主要内容

東京大学 新領域創成科学研究科 メディカル情報生命専攻 2022年8月実施 問題12

Author​

zephyr

Description​

We would like to know the probability that the string appears in a random protein sequence. Assume the sequence has random independent letters from the protein alphabet , and letter has probability . Define to be the probability that appears in a random sequence of length , given that the sequence ends with , where is a length-4 string.

(1) What is when ?

(2) What is when ?

Define to be without its final letter. Define to be with letter prepended to it. These definitions may be useful to answer the following questions.

(3) What is , in terms of , where is any length-4 string, when ?

(4) What is when ?

Define to be the product of the probabilities of the letters in . Define to be the set of all possible length-4 strings. These definitions may be useful to answer the following question.

(5) What is the probability that appears in a random sequence of length , in terms of ?

Kai​

(1)​

when :

If , then has not appeared by the time the sequence reaches length 4 with ending . Therefore, the probability .

(2)​

when :

If , then the sequence exactly matches , meaning has appeared. Therefore, the probability .

(3)​

in terms of when :

To find , we need to consider all possible sequences of length that could lead to a sequence ending with when an additional letter is appended. Specifically, depends on for all possible letters .

Since , we have:

(4)​

when :

If the sequence ends in at length , then has appeared, so .

(5)​

The probability that appears in a random sequence of length :

To find the total probability that appears in a sequence of length , we will consider 3 cases:

  1. : In this case, cannot appear, so the probability is 0.

  2. : The probability that appears in a sequence of length 4 is given by .

  3. : The probability that appears in a sequence of length is given by:

where is the product of the probabilities of the letters in .

Therefore, the probability that appears in a random sequence of length can be concluded as follows:

Knowledge​

概率论 随机序列 字符串出现概率

难点解题思路​

对于随机序列中特定字符串的出现概率问题，关键在于递推关系的构建以及边界条件的处理。通过定义恰当的递推公式，可以逐步推导出所需概率。

解题技巧和信息​

  1. 构建递推关系，考虑当前状态如何从前一个状态转移。
  2. 确定边界条件，并基于这些条件初始化递推公式。
  3. 注意概率的加总，确保所有可能的转移情况都被考虑在内。

重点词汇​

  • Probability: 概率
  • Sequence: 序列
  • Random: 随机的
  • Independent: 独立的
  • Recurrence relation: 递推关系

参考资料​

  1. Introduction to Probability Models, Chapter 3
  2. Probability and Statistics for Engineers and Scientists, Chapter 5